Skin Autofluorescence Assessment of Advanced Glycation End Products in Rheumatic Diseases

Sponsor
Bursa City Hospital
Study ID
NCT07329556
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Accepted

Study Details

Rheumatic diseases are chronic inflammatory conditions that can lead to long-term tissue damage and increased cardiovascular and metabolic risk. Advanced glycation end products (AGEs) are harmful molecules that accumulate in the body over time and are known to promote inflammation and oxidative stress. Increased AGE burden has been implicated in several chronic diseases; however, its role in rheumatic diseases has not been fully clarified. This observational, cross-sectional study aims to evaluate the accumulation of AGEs in patients with various rheumatic diseases compared with healthy individuals. AGE levels will be assessed non-invasively using skin autofluorescence measurements. By comparing AGE burden between patients and healthy controls, this study seeks to improve understanding of the potential role of AGEs in the pathophysiology of rheumatic diseases and to explore their usefulness as a non-invasive biomarker in clinical practice.

Key Dates

Start date
Jan 15, 2026
Status verified
Jan 2026
Primary completion
Jan 15, 2027
Completion
Apr 15, 2027

Study Design

Enrollment
300 participants (estimated)

Arms

  • Arm: Rheumatic Diseases Group
    Patients diagnosed with inflammatory rheumatic diseases undergoing skin autofluorescence measurement.
  • Arm: Healthy Control Group
    Age- and sex-matched healthy volunteers without a diagnosis of rheumatic disease.

Primary Outcome Measure

Skin Autofluorescence-Derived Advanced Glycation End Product Level [ Time Frame: Baseline (single study visit) ]

Central Contacts

Related Studies