A Study of Pasritamig (JNJ-78278343) in Combination With JNJ-86974680 for Treatment of Prostate Cancer

Part of paid clinical trials in Sarasota, Florida.

Sponsor
Janssen Research & Development, LLC
Study ID
NCT07319871
Phase
PHASE1
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Pasritamig — DRUG
    Pasritamig will be administered intravenously.
  • JNJ-86974680 — DRUG
    JNJ-86974680 will be administered orally.

Study Details

The purpose of this study is to identify the recommended phase 2 combination dose (RP2CD) of Pasritamig in combination with JNJ-86974680 in Part 1 (Dose finding) of the study and to determine how safe and tolerable the RP2CD is for treatment of participants with advanced prostate cancer in Part 2 (Dose expansion) of study.

Key Dates

Start date
Jan 14, 2026
Status verified
Jun 2026
Primary completion
Jan 7, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
40 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Part 1: Dose Finding
    Participants will receive pasritamig in combination with JNJ-86974680 to determine the recommended phase 2 combination dose (RP2CD) regimen.
  • Experimental: Part 2: Dose Expansion
    Participants will receive pasritamig in combination with JNJ-86974680 at the RP2CD as determined in Part 1 of the study to confirm the safety and anti-tumor activity.

Primary Outcome Measure

Number of Participants With Adverse Events (AEs) by Severity [ Time Frame: Up to 1 year 2 months ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Florida Cancer SpecialistsSarasotaFlorida34232-
Columbia University Medical CenterNew YorkNew York10032-
University Hospitals Cleveland Medical CenterClevelandOhio44106-

Find similar trials in Sarasota, FL

By condition
Prostate cancer
By specialty
OncologyProstate oncologyMen's healthUrology
By research site
Florida Cancer Specialists· Sarasota, FLColumbia University Medical Center· New York, NYUniversity Hospitals Cleveland Medical Center· Cleveland, OH

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