Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder

Part of paid clinical trials in New York, New York.

Sponsor
Icahn School of Medicine at Mount Sinai
Study ID
NCT07318480
Status
Recruiting
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Conditions

  • Cocaine Dependence
  • Cocaine Use Disorder
  • Substance Use Disorder (SUD)

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Direct Current Stimulator (tDCS) — DEVICE
    Participants will have two electrodes applied (one anode, one cathode) administering active (real) or sham (placebo, not real) tDCS stimulation of the dorsolateral prefrontal cortex. Stimulation will last 20 minutes per day, three days per week, for 5 weeks
  • Cognitive Reappraisal Training — BEHAVIORAL
    Cognitive reappraisal of drug cues during stimulation sessions

Study Details

The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder. Neuroimaging before and after stimulation will establish the neural correlates of recovery and allow predictions of outcomes, which will be assessed throughout the study and one month after its completion. Results could pave the way towards development of a new self-administered intervention to reduce craving when it is needed the most, enhancing recovery real-time and in the natural environment in people with cocaine addiction as generalizable to other drugs of abuse and other disorders of self-control.

Key Dates

Start date
Feb 25, 2026
Status verified
Mar 2026
Primary completion
Feb 28, 2030
Completion
Feb 28, 2030

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Active tDCS with Cognitive Reappraisal (CR)
    Active Transcranial Direct Current Stimulation (tDCS) (Soterix Medical mini-CT tDCS stimulator), and Cognitive Reappraisal (CR)
  • Experimental: Active tDCS
    Active Transcranial Direct Current Stimulation (tDCS), (Soterix Medical mini-CT tDCS stimulator)
  • Sham Comparator: Sham tDCS
    Sham (Placebo) Transcranial Direct Current Stimulation (tDCS), (Soterix Medical mini-CT tDCS stimulator)
  • Experimental: Sham tDCS with Cognitive Reappraisal (CR)
    Sham (Placebo) Transcranial Direct Current Stimulation (tDCS) (Soterix Medical mini-CT tDCS stimulator), and Cognitive Reappraisal (CR)

Primary Outcome Measure

fMRI blood-oxygenation level dependent (BOLD) signal [ Time Frame: At baseline and immediately after 5 weeks of tDCS. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Icahn School of Medicine at Mount SinaiNew YorkNew York10029
Rachel Drury
[email protected]
646-937-2875

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By research site
Icahn School of Medicine at Mount Sinai· New York, NY

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