A Study of Multiparametric Ultrasound Imaging (mpUS) for People With Endometrial Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07318415
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Multiparametric Ultrasound Imaging — DIAGNOSTIC_TEST
    multiparametric ultrasound (mpUS) imaging right before IVRT, right after the last IVRT, and at 3, 6 and 12 months after IVRT
  • The vaginal assessment score (VAS) — OTHER
    The vaginal assessment score (VAS) is a four-item measure that is administered to the patient to quantify and rate (none, mild, moderate, or severe) their perception of dryness, soreness, irritation, and pain (dyspareunia or painfulness to touch with external stimulation).

Study Details

The researchers are doing this study to see how well multiparametric ultrasound (mpUS) imaging can evaluate vaginal tissue before and after IVRT. IVRT is routinely used to treat endometrial cancer but can cause damage to the vaginal tissue (vaginal toxicity). Side effects of vaginal toxicity can include vaginal dryness, itching, soreness, discharge, narrowing or shortening of the vagina (stenosis), and vaginal fibrosis (hardening), which can affect sexual function. The researchers will also look at whether participants are able to complete (tolerate) all mpUS imaging for this study.

Key Dates

Start date
Dec 11, 2025
Status verified
Dec 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Multiparametric Ultrasound Imaging (mpUS)
    All participants in this study will receive standard intravaginal brachytherapy (IVRT) and multiparametric ultrasound (mpUS) imaging right before IVRT, right after the last IVRT, and at 3, 6 and 12 months after IVRT.

Primary Outcome Measure

feasibility of B-mode ultrasound imaging [ Time Frame: 1 year ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering at Basking Ridge (Consent Only)Basking RidgeNew Jersey07920
Kalad Alektiar, MD
212-639-7981
Memorial Sloan Kettering Monmouth (Consent Only)MiddletownNew Jersey07748
Kaled Alektiar, MD
212-639-7981
Memorial Sloan Kettering Bergen (Consent Only)MontvaleNew Jersey07645
Kaled Alektiar, MD
212-639-7981
Memorial Sloan Kettering Suffolk - Commack (Consent Only)CommackNew York11725
Kaled Alektiar, MD
212-639-7981
Memorial Sloan Kettering Westchester (Consent Only)HarrisonNew York10604
Kaled Alektiar, MD
212-639-7981
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Kaled Alektiar, MD
212-639-7981
Mark Burgess, PhD
[email protected]
Memorial Sloan Kettering Nassau (Consent Only)UniondaleNew York11553
Kaled Alektiar, MD
212-639-7981

Find similar trials in Basking Ridge, NJ

By condition
Endometrial cancer
By specialty
OncologyGynecologic oncologyWomen's health
By research site
Memorial Sloan Kettering at Basking Ridge (Consent Only)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Consent Only)· Middletown, NJMemorial Sloan Kettering Bergen (Consent Only)· Montvale, NJMemorial Sloan Kettering Suffolk - Commack (Consent Only)· Commack, NYMemorial Sloan Kettering Westchester (Consent Only)· Harrison, NYMemorial Sloan Kettering Cancer Center· New York, NY

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