Cognitive Rehabilitation for Veterans With PNES

Conditions

• Psychogenic Nonepileptic Seizures (PNES)

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Cognitive Rehabilitation And Functional Treatment (CRAFT) — BEHAVIORAL
  Cognitive rehabilitation tailored to improve cognition and participation in daily activities for Veterans with PNES

Study Details

Psychogenic nonepileptic seizures (PNES) reflect a subtype of functional neurological disorder (FND) that is common and extremely disabling in Veterans. Cognitive problems are highly prevalent in PNES, they reduce quality of life, and they severely limit daily functioning. Currently, there are no available treatments that target cognition to improve daily function in PNES or other FNDs, leaving a major gap in the literature. Cognitive re-habilitation improves daily functioning in Veterans with related neuropsychiatric disorders and has a high chance of success in Veterans with PNES. The proposed study will solicit direct input from Veterans with PNES via qualitative interviews to inform the design of a cognitive treatment workbook. The workbook will then be iteratively refined based on participatory feedback from Veterans with PNES and their treatment providers. The full cognitive intervention protocol will be pilot tested to inform a fully powered RCT. Results will support a line of research that aims to improve cognition and function in Veterans with PNES and related FNDs.

Key Dates

Start date

Mar 2, 2026

Status verified

Mar 2026

Primary completion

Jul 1, 2031

Completion

Jul 1, 2031

Study Design

Enrollment

47 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Arms

• Other: Intervention
  Single arm of pilot trial testing the cognitive rehabilitation intervention

Primary Outcome Measure

WHODAS 2.0 Total Score [ Time Frame: Once at baseline (prior to the intervention) and once following the 8-12 week intervention. ]

Central Contacts

• Madeleine R Lefkowitz, BS
  (401) 127-7100
  [email protected]
• Alison Gorbatov
  (401) 271-7100
  [email protected]

Locations (1)

Find similar trials in Providence, RI