Individual Differences in Gait and Osteoarthritis Pain

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
University of Pittsburgh
Study ID
NCT07308873
Status
Recruiting
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Conditions

  • Chronic Knee Pain
  • Chronic Pain
  • Knee Osteoarthritis (OA)

Eligibility Criteria

Sex
ALL
Age
45 Years - 80 Years
Healthy Volunteers
Not accepted

Study Details

The goal of this observational study is to look at inter-individual differences in knee osteoarthritis (OA) walking pain and performance. The main questions this study aims to answer are: Why do some people with knee osteoarthritis have more severe disabling pain than others, even though the degenerative changes in their knees are similar? What are the factors that contribute to walking pain in people with knee osteoarthritis? Participants will complete surveys, perform physical function tasks, get a knee X-ray and MRI, undergo non-invasive brain imaging, and undergo sensory testing.

Key Dates

Start date
Jan 7, 2026
Status verified
Jan 2026
Primary completion
Aug 1, 2030
Completion
Aug 1, 2030

Study Design

Enrollment
300 participants (estimated)

Arms

  • Arm: Chronic knee pain with knee osteoarthritis
    Adults 45-80 years old who have moderately severe knee osteoarthritis. They must have experienced knee pain for greater than 6 months and rate their daily knee pain at \>3 on a 0-10 numeric rating scale.

Primary Outcome Measure

6 minute walk test pain intensity [ Time Frame: 6 minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UPMC Pain Medicine at Centre CommonsPittsburghPennsylvania15206-

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UPMC Pain Medicine at Centre Commons· Pittsburgh, PA

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