Post-Filter Hematocrit

Part of paid clinical trials in Iowa City, Iowa.

Sponsor
Gwyndolyn M. Radford
Study ID
NCT07293936
Status
Recruiting
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Conditions

  • Continuous Renal Replacement Therapy
  • Hemofilter Clotting
  • Renal Failure

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Calculated Post-Filter Hematocrit — OTHER
    using the formula: HCTpost=HCTpre/(FF(HCTpre-1)+1)
  • Measured Post-Filter Hematocrit — OTHER
    Measured from blood sample taken from CRRT machine

Study Details

Filter clotting is a major complication of continuous renal replacement therapy (CRRT), resulting in blood loss, reduced treatment efficacy, and increased cost. One modifiable factor associated with filter clotting is filtration fraction (FF), or the proportion of plasma water being removed from the blood over the course of the filter. In convention, a cutoff of FF\<20-30% has been used to prevent hemofilter clotting, but no evidence correlating FF with hemofilter clotting has been documented. Some experts have proposed that post-filter hematocrit (Hct) could be a more direct marker for determining hemofilter clotting risk, but evidence supporting clinical utility of this marker is lacking. HCTpost=HCTpre/(FF(HCTpre-1)+1) In our proposed validation study, we hope to determine whether our formula for post-filter Hct provides accurate results when compared to measured values. The information obtained from this study will potentially justify the use of utilizing the formula in future studies. The procedure of this study is collecting blood samples from the post-filter lines of patients on CRRT at different time points and different flow rates. This will be considered the "measured post-filter hematocrit" which will then be compared to the calculated formula above, using the other values obtained from daily labs (for pre-filter hematocrit) and CRRT machine settings.

Key Dates

Start date
Mar 15, 2025
Status verified
Dec 2025
Primary completion
Feb 1, 2026
Completion
Mar 15, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Other: CRRT patients
    All participants will receive the same "intervention" of both measuring and calculating post-filter hematocrit.

Primary Outcome Measure

Agreement between measured and calculated post-filter hematocrit values. [ Time Frame: Participation begins at consent and includes a single study procedure in which four post-filter blood samples are collected over ~40 minutes. Participation ends after the final draw. Generally, no longer than 1 day. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Iowa Hospitals and ClinicsIowa CityIowa52242
Gwyndolyn M Radford, MD
[email protected]
319-384-9668

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By research site
University of Iowa Hospitals and Clinics· Iowa City, IA

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