A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for High-Grade Appendiceal and Colorectal Adenocarcinoma With Peritoneal Metastasis

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT07291180
Status
Recruiting
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Conditions

  • Appendiceal Cancer
  • Colorectal Adenocarcinoma
  • Peritoneal Metastases

Eligibility Criteria

Sex
ALL
Age
18 Years - 81 Years
Healthy Volunteers
Not accepted

Interventions

  • Mass-based response testing (MRT) — DEVICE
    Travera has developed a clinical workflow that combines single-cell mass measurements with inline brightfield imaging and machine-learning based image classification to perform mass-based response testing (MRT) directly on live tumor cells collected from patients. MRT enables tumor cells across a wide range tissue sample formats to be dosed with a panel of drugs in vitro, agnostic to malignancy or drug mechanism.

Study Details

This study will evaluate the role of mass-based response testing (MRT) to select and deliver personalized hyperthermic intraperitoneal chemotherapy (HIPEC) regimens to patients with peritoneal metastasis (PM) from high-grade appendiceal adenocarcinomas (HGAA) and colorectal cancer (CRC).

Key Dates

Start date
Mar 31, 2026
Status verified
Mar 2026
Primary completion
Oct 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: MRT
    Participants with high-grade appendiceal and colorectal peritoneal metastasis will receive MRT to select and deliver personalized HIPEC regimens to participants undergoing IHIPEC

Primary Outcome Measure

Feasibility of performing MRT to select and deliver personalized HIPEC [ Time Frame: at end of study, up to 12 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Yale New Haven HospitalNew HavenConnecticut06510-

Find similar trials in New Haven, CT

By research site
Yale New Haven Hospital· New Haven, CT

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