Using a Steroid Mouthwash to Prevent Mouth Sores During Chemotherapy

Conditions

• Oral Mucositis Due to Chemotherapy

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Dexamethasone Mouthwash — DRUG
  Participants will use 10 mL of alcohol-free dexamethasone mouthwash (0.5 mg per 5 mL) as a swish-and-spit rinse for 2 minutes, four times per day. Use will begin during the first week of chemotherapy and continue for at least 8 weeks.

Study Details

The goal of this clinical trial is to learn if a steroid mouthwash (dexamethasone) can prevent mouth sores caused by chemotherapy in adults with cancer. The main questions it aims to answer are: Does using dexamethasone mouthwash before and during chemotherapy lower the chance of getting moderate to severe mouth sores? Can this approach reduce pain and improve comfort during chemotherapy? Researchers will compare patients using the mouthwash to a historical group of patients who received similar chemotherapy but did not use the mouthwash, to see if the mouthwash helps prevent mouth sores. Participants will: Use a steroid mouthwash (4 times daily) for up to 8 weeks during chemotherapy Complete a short weekly survey about mouth discomfort during infusion visits

Key Dates

Start date

Apr 30, 2026

Status verified

Mar 2026

Primary completion

Jul 31, 2027

Completion

Jan 31, 2028

Study Design

Enrollment

45 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Arms

• Experimental: Dexamethasone Mouthwash Intervention Group
  Participants in this arm will receive an alcohol-free dexamethasone mouthwash (0.5 mg per 5 mL solution). They will be instructed to swish and spit 10 mL of the mouthwash for 2 minutes, four times daily, beginning in the first week of chemotherapy. Mouthwash use will continue for at least 8 weeks.

Primary Outcome Measure

Incidence of Grade ≥2 Oral Mucositis [ Time Frame: From start of chemotherapy through completion of first chemotherapy cycle (up to 8 weeks) ]

Central Contacts

• Jaymes H Collins, PhD
  225-924-7142
  [email protected]
• Ericka Seidemann, MA
  225-231-5296
  [email protected]

Locations (1)

Find similar trials in Baton Rouge, LA