Evaluation of Clinical Outcomes and Acceptability of an Anatomical Classification for Placenta Accreta Spectrum

Conditions

• Placenta Accreta

Eligibility Criteria

Sex

FEMALE

Age

18 Years - 55 Years

Healthy Volunteers

Not accepted

Interventions

• Total Hysterectomy — PROCEDURE
  Removal of entire uterus
• Modified subtotal hysterectomy — PROCEDURE
  When partial tissue integrity is preserved
• One-Step Conservative Surgery — PROCEDURE
  Considered when significant healthy myometrium is preserved

Study Details

This study evaluates the clinical implementation of intra-operative topographic classification system for PAS. In addition to a standard of care risk stratification prenatal ultrasound for patients with a risk of PAS, this study adds an additional intraoperative surgical staging protocol to validate the classification system, improve surgical approach, and significantly clinical outcomes of pregnant people with an a prior risk of PAS. The study will involve pregnant patients with PAS risk factor, include data collection spanning prenatal assessment, intraoperative classification, surgical technique implementation and postoperative analysis. The anticipated study duration is approximately 36-48 months.

Key Dates

Start date

Dec 1, 2025

Status verified

Dec 2025

Primary completion

Dec 31, 2027

Completion

Dec 31, 2028

Study Design

Enrollment

60 participants (estimated)

Arms

• Arm: PAS
  Patients with placental accreta undergoing planned surgical intervention for PAS

Primary Outcome Measure

Ultrasound assessment [ Time Frame: 0-30 days prior to planned surgery ]

Central Contacts

• Dana Levin-Lopez, MPH
  310-794-8893
  [email protected]

Locations (1)

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