Cannabidiol and Alcohol Use Disorder Phenotypes

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT07279558
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Full-Spectrum Cannabidiol (CBD) — DRUG
    Dose: Approximately 200mg of full-spectrum CBD (\<0.3% THC) Active Ingredients: Full spectrum hemp extract Other Ingredients: Hemp seed oil, glycerin, gelatine.
  • Broad-Spectrum Cannabidiol (CBD) — DRUG
    Dose: Approximately 200mg of broad-spectrum CBD, (0% THC) Active Ingredients: Broad spectrum hemp extract Other Ingredients: Hemp seed oil, glycerin, gelatine.
  • Placebo — DRUG
    Active Ingredients: N/A Other Ingredients: Hemp seed oil, glycerin, gelatine.

Study Details

The goal of this study is to learn how CBD affects drinking in people who drink alcohol regularly. Researchers want to see if CBD can help people drink less and reduce problems related to alcohol use.

Key Dates

Start date
Mar 31, 2026
Status verified
Mar 2026
Primary completion
Aug 31, 2029
Completion
Aug 31, 2029

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Full-Spectrum CBD
    Subjects will take 200 mg of full-spectrum CBD (\[fsCBD\] CBD that contains \<0.3% THC) daily for 8 weeks. The total dose is split into a morning and evening dose, such that participants in the fsCBD condition will take approximately 100mg fsCBD in the morning (2 capsules) and 100mg fsCBD in the evening (2 capsules).
  • Experimental: Broad- Spectrum CBD
    Subjects will take 200 mg of broad-spectrum CBD (\[bsCBD\] CBD that contains no THC) daily for 8 weeks. The total dose is split into a morning and evening dose, such that participants in the bsCBD condition will take approximately 100mg bsCBD in the morning (2 capsules) and 100mg bsCBD in the evening (2 capsules).
  • Placebo Comparator: Placebo
    Subjects will take a matching placebo solution (100% Hemp Seed Oil) daily for 8 weeks. The total dose is split into a morning and evening dose, such that participants in the condition will take approximately 100mg hemp seed oil in the morning (2 capsules) and 100mg hemp seed oil in the evening (2 capsules).

Primary Outcome Measure

Alcohol Self-Administration During the Bar Lab Task [ Time Frame: Week 8 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Colorado School of Medicine- Anschutz Medical CampusAuroraColorado80045
Hollis C Karoly, PhD
[email protected]
303-724-7179
Landon C Tomb, MS
[email protected]
225-244-3429

Find similar trials in Aurora, CO

By condition
Substance use disorder
By specialty
Behavioral healthAddiction medicine
By research site
University of Colorado School of Medicine- Anschutz Medical Campus· Aurora, CO

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