Study of [212Pb]Pb-DOTAM-MAM279 ([212Pb]Pb-MP0712) in Patients With Small Cell Lung Cancer and Other DLL3 Expressing Solid Tumors

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Molecular Partners AG
Study ID
NCT07278479
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

  • Extrapulmonary Neuroendocrine Carcinoma (EP-NEC)
  • Gastroenteropancreatic NEC (GEP NEC)
  • Large Cell Neuroendocrine Carcinoma
  • Large Cell Pulmonary Neuroendocrine Carcinoma of the Lung (LCNEC)
  • NEC of the Bladder
  • Other DLL3 Expressing epNEC
  • Small Cell Lung Cancer (SCLC)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • [212Pb]Pb-MP0712 — DRUG
    Radioligand Therapy
  • [203Pb]Pb-MP0712 — OTHER
    Radioligand Imaging Agent

Study Details

The purpose of this study is to evaluate the safety, tolerability, dosimetry and preliminary efficacy of \[212Pb\]Pb-MP0712, in patients aged ≥18 years with Small Cell Lung Cancer and other locally advanced or metastatic DLL3 positive tumors.

Key Dates

Start date
May 18, 2026
Status verified
May 2026
Primary completion
Sep 30, 2028
Completion
Sep 30, 2032

Study Design

Enrollment
138 participants (estimated)
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: [203Pb]Pb-DOTAM-MAM279/[212Pb]Pb-DOTAM-MAM279
    Patients will receive \[203Pb\]Pb-DOTAM-MAM279 for Imaging/Dosimetry followed by \[212Pb\]Pb-DOTAM-MAM279 for treatment

Primary Outcome Measure

To assess incidence and severity of safety events following administration of [212Pb]Pb-DOTAM-MAM279 [ Time Frame: until 5 years after last dose ]

Central Contacts

Locations (5)

FacilityCityStateZIPSite coordinators
Emory University HospitalAtlantaGeorgia30322
Ryan Hanula
[email protected]
404-778-5141
United TheranosticsGlen BurnieMaryland21061
Amanda Huggins
[email protected]
667-HOPENOW
Nebraska Cancer SpecialistsOmahaNebraska68130
Research Director
[email protected]
402-955-2691
United TheranosticsPrincetonNew Jersey08540
Amanda Huggins
[email protected]
667-HOPENOW
University Hospitals Cleveland Medical CenterClevelandOhio44106
Dr A.Dowlati
[email protected]
216-368-1122

Find similar trials in Atlanta, GA

By research site
Emory University Hospital· Atlanta, GAUnited Theranostics· Glen Burnie, MDNebraska Cancer Specialists· Omaha, NEUnited Theranostics· Princeton, NJUniversity Hospitals Cleveland Medical Center· Cleveland, OH

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