Evaluating a New Therapy for Dry Eye in Patients With Sjögren's Syndrome

Conditions

• Sjogren Syndrome With Keratoconjunctivitis

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• TRYPTYR (Acoltremon ophthalmic solution 0.003%) — DRUG
  Drop to be instilled before and after endpoint measurement.

Study Details

This study will evaluate the effect of TRYPTYR in patients with Sjögren's syndrome-related dry eye disease. The goal is to determine whether TRYPTYR can improve symptoms and signs of dry eye in this specific patient population.

Key Dates

Start date

Dec 2, 2025

Status verified

Dec 2025

Primary completion

Dec 31, 2026

Completion

Dec 31, 2026

Study Design

Enrollment

35 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Arms

• Experimental: Study eye
  The study eye is the eye with the lower pre-drop unanesthetized Schirmer score performed at the baseline visit.

Primary Outcome Measure

Change from pre-instillation to 3 minutes post-TRYPTYR instillation in study eye unanesthetized Schirmer's test at Visit 1 (baseline) [ Time Frame: 3 minutes ]

Central Contacts

• Gina Thomas
  9412634784
  [email protected]

Locations (1)

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