Restorative Neurophysiology: Backing up and Restoring the Brain (BandR)

Conditions

• Adults With Variability in Their Mood

Eligibility Criteria

Sex

ALL

Age

18 Years - 65 Years

Healthy Volunteers

Accepted

Interventions

• Transcranial alternating current stimulation (tACS) — DEVICE
  Transcranial alternating current stimulation (tACS) is a widely used non-invasive brain stimulation method. The concept underlying alternating current is to simulate the naturally occurring rhythmic pattern of electrophysiological activity of the brain, which can be detected by electroencephalography (EEG). It involves the application of electrodes onto the scalp, which deliver sinusoidal alternating electric currents.
• Neuro/biofeedback — BEHAVIORAL
  Participants will be shown their their brain EEG recordings and parameters from vocal recordings from their "backup" day, and asked to attempt to use behavioral strategies to match the recording
• Recall — BEHAVIORAL
  Participants will be given their subjective ratings and notes from a journaling interval to use as a target to restore their mood to how they were feeling on the Visit 1 backup day
• Physiological stimulation — DEVICE
  Facial electrical stimulation, and chest-worn vibroacoustic stimulation will be used to affect facial muscle activity and peripheral physiology to better approximate previously assessed states.

Study Details

Study to examine the extent to which neurophysiological states recorded for a specific person on one day can be induced on a subsequent day

Key Dates

Start date

Jan 1, 2026

Status verified

Mar 2026

Primary completion

Mar 1, 2029

Completion

Mar 1, 2029

Study Design

Enrollment

60 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Recall + Stimulation + Neurofeedback
  Participants will be given their subjective ratings and notes from the first session and asked to recreate how they were feeling at their first session during recall-only blocks. In addition, during neurofeedback and stimulation blocks, they will be given access to technologies for restoring neurophysiological features from the first assessment, including their 1) brain state, 2) facial muscle activity, and 3) heart rate variability. They will be provided with this information and asked to match their previous recordings during the neurofeedback blocks, and stimulated using Transcranial alternating current stimulation (TACS), electromyography (EMG), and vibroacoustic stimulation during the stimulation blocks.

Primary Outcome Measure

Mean Change in electroencephalogram (EEG) Activity Across 4 Frequency Bands from Baseline [ Time Frame: 4 months ]

Central Contacts

• Greg Siegle, PhD
  412-864-3501
  [email protected]

Locations (1)

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