A Study of Voice as a Way to Monitor for Side Effects in People Receiving CAR T-Cell Therapy

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07249528
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Audio Tasks — DIAGNOSTIC_TEST
    Voice recordings will be collected at baseline (pre-infusion), twice daily from Day 0 through Day +10, and, if ICANS develops, twice daily until three days after clinical resolution. A final voice recording will also be performed on Day +30

Study Details

The purpose of this study is to collect voice recordings and nervous system (neurologic) assessments from people with non-Hodgkin lymphoma (NHL) or multiple myeloma (MM) who are receiving standard treatment with CAR T-cell therapy. Researchers will study whether these voice recordings and assessments are a practical (feasible) way to monitor for immune effector cell-associated neurotoxicity syndrome (ICANS). Feasibility will be measured by tracking how many participants join the study and complete the assessments.

Key Dates

Start date
Apr 17, 2026
Status verified
Apr 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
20 participants (estimated)

Arms

  • Arm: Participants diagnosed with non-Hodgkin lymphoma or multiple myeloma
    Participants must have pathologically confirmed Diagnosed with non-Hodgkin lymphoma or multiple myeloma.

Primary Outcome Measure

Number of daily voice recordings collected [ Time Frame: 30 days after baseline ]

Central Contacts

Locations (8)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering at Basking Ridge (Consent Only)Basking RidgeNew Jersey07920
Roni Shoulval, MD, PhD
646-888-3483
Memorial Sloan Kettering Monmouth (Consent only)MiddletownNew Jersey07748
Roni Shouval, MD, PhD
646-888-3483
Memorial Sloan Kettering Bergen (Consent Only)MontvaleNew Jersey07645
Roni Shouval, MD, PhD
646-888-3483
Memorial Sloan Kettering Suffolk-Commack (Consent Only)CommackNew York11725
Roni Shouval, MD, PhD
646-888-3483
Memorial Sloan Kettering Westchester (Consent only)HarrisonNew York10604
Roni Shouval, MD, PhD
646-888-3483
Memorial Sloan Kettering Cancer Center (All Protocol Activites)New YorkNew York10065
Roni Shouval, MD, PhD
646-888-3483
Weill Cornell Medical Center (Data Analysis Only)New YorkNew York10021
Alexandros Sigaras
[email protected]
646-962-5634
Memorial Sloan Kettering Nassau (Consent Only)Rockville CentreNew York11553
Roni Shouval, MD, PhD
646-888-3483

Find similar trials in Basking Ridge, NJ

By condition
Multiple myeloma
By specialty
OncologyBlood cancer
By research site
Memorial Sloan Kettering at Basking Ridge (Consent Only)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Consent only)· Middletown, NJMemorial Sloan Kettering Bergen (Consent Only)· Montvale, NJMemorial Sloan Kettering Suffolk-Commack (Consent Only)· Commack, NYMemorial Sloan Kettering Westchester (Consent only)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activites)· New York, NY

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