Tumor-Derived Extracellular Vesicles for Noninvasive Molecular Classification of Kidney Cancer

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT07243067
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • Proteomic profiling of urinary EVs — OTHER
    EV isolation and mass spectrometry.
  • Blood sample collection — PROCEDURE
    Blood samples collected pre- and post-nephrectomy

Study Details

This is a correlative (lab-based) study aiming to identify protein markers in urine extracellular vesicles (EVs) that can be used to develop non-invasive molecular tests for patients with renal cell carcinoma (RCC). Aim 1 will use urine collected previously in biorepository. Aim 2 will prospectively collect blood specimens pre and post nephrectomy.

Key Dates

Start date
Jul 15, 2026
Status verified
Feb 2026
Primary completion
Apr 30, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
300 participants (estimated)

Arms

  • Arm: Clear-cell RCC
    Participants with clear-cell RCC
  • Arm: Papillary RCC
    Participants with papillary RCC
  • Arm: Chromophobe RCC
    Participants with chromophobe RCC
  • Arm: Benign Renal Tumor
    Participants with benign renal tumors

Primary Outcome Measure

Differentiate tumor-derived extracellular vesicle (tdEV) surface proteins expressed in benign vs malignant renal tumors [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic in RochesterRochesterMinnesota55905
Clinical Trials Referral Office
[email protected]
855-776-0015
Fabrice Lucien-Matteoni, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Rochester, MN

By condition
Kidney cancer
By specialty
OncologyUrology
By research site
Mayo Clinic in Rochester· Rochester, MN

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