Potatoes, Type 2 Diabetes, and Cardiometabolic Health

Part of paid clinical trials in Blacksburg, Virginia.

Sponsor
Virginia Polytechnic Institute and State University
Study ID
NCT07229482
Status
Not Yet Recruiting

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Conditions

  • Blood Pressure
  • Cardiometabolic Health
  • T2D

Eligibility Criteria

Sex
ALL
Age
50 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Controlled diet: Potato-rich healthy dietary pattern — OTHER
    Following a 2-week eucaloric lead-in diet, participants will be provided and consume a potato-rich healthy dietary pattern for 12 weeks. The intervention diet will be eucaloric and matched for macronutrient composition with the control diet. Whole white potatoes will be incorporated into the intervention diet in different forms. This diet will have an healthy eating index (HEI) score of 85.
  • Controlled diet: Typical Western-style dietary pattern — OTHER
    Following a 2-week eucaloric lead-in diet, participants will be provided and consume a typical Western-style dietary pattern for 12 weeks. The control diet will be potato-free, eucaloric, and matched for macronutrient composition with the intervention diet. This diet will have an healthy eating index (HEI) score of 58.

Study Details

Type 2 diabetes (T2D) is a major chronic health condition which increases risk of coronary artery disease, frailty, cognitive decline, and mortality. Additionally, hypertension is a major comorbidity for individuals with T2D, further increasing the risk of adverse cardiovascular outcomes. The prevalence of both conditions increases with advancing age. There is an urgent need to identify new approaches to prevent the development of T2D and improve cardiometabolic health in older adults 50-70 years of age. Whole white potatoes are an unprocessed food rich in essential nutrients often under-consumed by Americans, including potassium, fiber, magnesium, vitamins C and B6, and phytochemicals. Each of these nutrients individually are associated with cardiometabolic health benefits. Potatoes account for a significant amount of the intake of these nutrients in the US diet and are well-positioned to be a foundational element of a healthy dietary pattern. However, there are few interventional studies evaluating the effect of potatoes on cardiometabolic health, and the evidence from observational studies is mixed, leaving a significant gap in knowledge regarding the potential for potatoes to be included in healthy dietary patterns. The results of our proposed study will provide foundational data that inform future dietary guidelines regarding the inclusion of white potatoes as part of a healthy US dietary pattern.

Key Dates

Start date
Jun 30, 2026
Status verified
Apr 2026
Primary completion
Oct 31, 2028
Completion
Mar 31, 2029

Study Design

Enrollment
42 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Potato-rich healthy diet pattern
    Following a 2-week eucaloric lead-in diet, participants will be provided and consume a potato-rich healthy dietary pattern for 12 weeks.
  • Active Comparator: Typical Western-style dietary pattern
    Following a 2-week eucaloric lead-in diet, participants will be provided and consume a typical Western-style dietary pattern for 12 weeks.

Primary Outcome Measure

Change in glucose tolerance from baseline to 12 weeks post potato-rich healthy diet vs typical Western-style diet [ Time Frame: 2-hour test in laboratory, 2 timepoints (baseline, 12-weeks post intervention diets) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Virginia Polytechnic Institute and State UniversityBlacksburgVirginia24061
Dennis Cladis, PhD
[email protected]
540-231-5208
Elaina Marinik, PhD
[email protected]
540-231-0923

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