Timing of Opioid Administration and Postoperative Respiratory Depression.

Part of paid clinical trials in Mount Clemens, Michigan.

Sponsor
Wayne State University
Study ID
NCT07227389
Status
Not Yet Recruiting

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Conditions

  • Opioid Induced Respiratory Depression
  • Postoperative Respiratory Complications
  • Respiratory Complications

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Respiratory volume monitoring — DIAGNOSTIC_TEST
    Noninvasive continuous respiratory monitoring utilizing bio-impedance to detect tidal volumes, respiratory rate, and minute ventilation.

Study Details

The goal of this study is to determine if a relationship can be detected between the administration of an opioid and quantitative respiratory depression in spontaneously breathing non-intubated patients who have undergone general anesthesia and have received perioperative opioids. The primary aim is to determine the temporal effect of opioid administration on respiratory depression as assessed by minute ventilation with a reduction of at least 20% in the percent of predicted minute ventilation. A secondary aim is to determine a dose response of opioid administration and its effect on minute ventilation. The investigators aim to determine the influence of opioid administration on minute ventilation on spontaneously breathing patients during post-anesthesia care unit (PACU) stay.

Key Dates

Start date
Dec 31, 2025
Status verified
Nov 2025
Primary completion
Dec 1, 2028
Completion
Jan 1, 2029

Study Design

Enrollment
52 participants (estimated)

Arms

  • Arm: Study group
    Patients receiving general anesthesia with an expected anesthetic time of at least 2 hours

Primary Outcome Measure

Respiratory interventions 1 [ Time Frame: Within 4 hours of patient admittance to Post Anesthetic Care Unit (PACU) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Detroit Medical CenterMount ClemensMichigan48043

Find similar trials in Mount Clemens, MI

By research site
Detroit Medical Center· Mount Clemens, MI

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