Exercise and Mortality in Middle-Aged and Older Adults

Conditions

• Overall Survival (All-cause Mortality)

Eligibility Criteria

Sex

ALL

Age

55 Years - 74 Years

Healthy Volunteers

Not accepted

Interventions

• Control — BEHAVIORAL
  0 or less than 1 day per week, with each session, on average \< 15 minutes.
• Exercise — BEHAVIORAL
  \>/= 2 days per week of moderate or vigorous intensity, with each session, on average, \>/=20 minutes in duration.

Study Details

This protocol is a retrospective study using the observational data of the the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial with over 150,000 participants aged 55-74 years to conduct a target trial emulation to examine the association between self-reported exercise and all cause and cause-specific mortality in apparently healthy, middle-aged and older adults. The PLCO includes assessments of participants' exercise level at two timepoints: at randomization into the PLCO trial (Q0) and 5-7 years after randomization into the PLCO (Q1).

Key Dates

Start date

Apr 1, 2026

Status verified

Feb 2026

Primary completion

Aug 6, 2026

Completion

Aug 6, 2026

Study Design

Enrollment

19,000 participants (estimated)

Arms

• Arm: Arm 1 - Control
  0 or less than 1 day per week, with each session, on average \< 15 minutes.
• Arm: Arm 2 - Exercise
  \>/= 2 days per week of moderate or vigorous intensity, with each session, on average, \>/=20 minutes in duration.

Primary Outcome Measure

Overall survival (all-cause mortality) [ Time Frame: up to 19 years ]

Central Contacts

• Lee W Jones, PhD
  626-218-3844
  [email protected]
• Lennie Wong, PhD
  626-218-3844
  [email protected]

Locations (1)

Find similar trials in Duarte, CA