The Effects of Ketone Supplements With Carbohydrates on Cycling Performance Above Lactate Threshold

Part of paid clinical trials in Norman, Oklahoma.

Sponsor
University of Oklahoma
Study ID
NCT07224282
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Exogenous Ketosis

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Ketone supplementation — DIETARY_SUPPLEMENT
    30-gram carbohydrate beverage with 5 grams of R-1,3-Butanediol every 30 minutes of experimental visit
  • Carbohydrate — DIETARY_SUPPLEMENT
    30-gram carbohydrate beverage with bitter flavoring

Study Details

The goal of this clinical trial is to determine whether a ketone supplement with carbohydrates extends time to fatigue during cycling compared with a carbohydrate-only supplement in healthy, trained cyclists aged 18-55. The main questions it aims to answer are: Is the time to fatigue increased with ketone supplementation and carbohydrates compared to carbohydrates alone? Will ketone supplementation with carbohydrates produce lower blood lactate concentrations compared to carbohydrates alone? Participants will: * Perform a staged maximal cycling exercise test on a stationary bicycle. * Finger prick to obtain a drop of blood for lactate measurements. * Wear a mask connected to a metabolic cart to measure breath contents. * Perform a cycling exercise test to fatigue for at least one hour. * Consume either a ketone supplement with carbohydrates or a carbohydrate supplement during the exercise at least 4 times. * Finger prick to obtain a drop of blood to measure blood lactate, ketones, and glucose.

Key Dates

Start date
Nov 17, 2025
Status verified
Nov 2025
Primary completion
Mar 9, 2026
Completion
May 3, 2026

Study Design

Enrollment
15 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Ketone supplementation with carbohydrates
  • Placebo Comparator: Carbohydrate supplement only

Primary Outcome Measure

Time to fatigue [ Time Frame: Through study completion, an average of 2 weeks. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of OklahomaNormanOklahoma73019
Rebecca Larson, Ph.D
[email protected]
405-325-5211

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By research site
University of Oklahoma· Norman, OK