Handgrip Training and Brain Blood Flow Regulation

Part of paid clinical trials in Tallahassee, Florida.

Sponsor
Florida State University
Study ID
NCT07223645
Status
Recruiting
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Conditions

  • Inactivity/Low Levels of Exercise

Eligibility Criteria

Sex
ALL
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Handgrip Training — DEVICE
    Handgrip training 3 days per week for 8 weeks

Study Details

This study aims to investigate the effect of isometric handgrip training on brain blood vessel function in physically inactive adults. Isometric handgrip training is a promising strategy for lowering blood pressure and improving vascular health, but no previous investigations have studied the effect of training on markers of brain blood vessel function. Based on previous work showing improvements in vascular function after isometric handgrip training, we hypothesize that isometric handgrip training will improve key markers of cerebrovascular function.

Key Dates

Start date
Oct 27, 2025
Status verified
Nov 2025
Primary completion
Oct 27, 2027
Completion
Oct 27, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Isometric Handgrip Training - Intervention
    Participants will perform moderate-intensity handgrip training three days per week for eight weeks using a handheld device.
  • Sham Comparator: Isometric Handgrip Training - Sham
    Participants will perform very low-intensity handgrip training three days per week for eight weeks using a handheld device.

Primary Outcome Measure

Change in middle cerebral artery blood velocity reactivity to hypercapnia [ Time Frame: Up to 9 weeks ]

Locations (1)

FacilityCityStateZIPSite coordinators
Florida State UniversityTallahasseeFlorida32306
Joseph Watso, PhD
[email protected]
850-644-5260

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Florida State University· Tallahassee, FL

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