Impact of Smell Testing on Health Outcomes

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
Monell Chemical Senses Center
Study ID
NCT07222891
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • Olfactory Dysfunction
  • Wellbeing

Eligibility Criteria

Sex
ALL
Age
7 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Patient-centered information and education — BEHAVIORAL
    Participants with smell dysfunction will receive patient-centered information and education about i) community engagement with individuals with smell loss, ii) available counseling and iii) medical support.

Study Details

Smell dysfunction is frequent yet neglected. The sense of smell plays a crucial role in signaling disease, safety, and overall quality of life. However, the significance of a functional sense of smell in terms of health and well-being is often overlooked until one experiences a loss of smell due to injury or disease. Research demonstrates that individuals are often not self-aware of their smell dysfunction (i.e. they do not spontaneously report smell dysfunction as a symptom), especially if the changes are gradual, as in normal aging. Patients with smell dysfunction experience a marked reduction in quality of life, poor mental health, nutritional health, and brain health as well as increased 5- and 10-year mortality in older adults. This study explores whether or not enabling healthcare providers to offer resources and guidance on coping strategies for smell dysfunction improves health and wellbeing in those who experience it.

Key Dates

Start date
Nov 1, 2025
Status verified
Oct 2025
Primary completion
Sep 30, 2027
Completion
Nov 30, 2027

Study Design

Enrollment
1,000 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Smell dysfunction detection and educational intervention
    Participants will take smell tests and receive educational materials on smell dysfunction.
  • No Intervention: Normosmia
    No intervention

Primary Outcome Measure

Measuring depression symptoms using the PHQ-9 score [ Time Frame: PHQ-9 is completed at baseline, during 1 month follow-up session, and during the 6 month follow-up. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Monell Chemical Senses CenterPhiladelphiaPennsylvania19104
Ryann Kolb
[email protected]
2156092024
Valentina Parma
[email protected]
Valentina Parma (PRINCIPAL_INVESTIGATOR)
Pamela Dalton (PRINCIPAL_INVESTIGATOR)
Danielle Reed (PRINCIPAL_INVESTIGATOR)

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Monell Chemical Senses Center· Philadelphia, PA

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