A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003)

Part of paid clinical trials in Bakersfield, California.

Sponsor
Merck Sharp & Dohme LLC
Study ID
NCT07222488
Phase
PHASE1/PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • MK-3120 — BIOLOGICAL
    Intravesical administration at one of three doses per protocol

Study Details

Researchers are looking for new ways to treat high-risk non-muscle invasive bladder cancer (HR NMIBC). NMIBC is cancer in the tissue that lines the inside of the bladder and has not spread to the bladder muscle or outside of the bladder. In standard treatment for HR NMIBC, doctors first remove the tumor with a procedure called transurethral resection of the bladder tumor (TURBT). Researchers want to learn if using MK-3120, the study medicine, can treat HR NMIBC after TURBT. The goal of this study is to learn about the safety of MK-3120 and if people tolerate it.

Key Dates

Start date
Dec 9, 2025
Status verified
Apr 2026
Primary completion
Feb 28, 2029
Completion
Feb 28, 2029

Study Design

Enrollment
45 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: MK-3120
    Participants will be administered MK-3120 once weekly for the first 6 weeks, followed by once monthly for 9 months.

Primary Outcome Measure

Number of Participants Who Experience a Dose-limiting Toxicity (DLT) [ Time Frame: Up to approximately 5 weeks ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Michael G Oefelein Clinical Trials ( Site 0005)BakersfieldCalifornia93301
Study Coordinator
661-310-1063
Carolina Urologic Research Center ( Site 0006)Myrtle BeachSouth Carolina29572
Study Coordinator
843-449-1010

Find similar trials in Bakersfield, CA

By condition
Bladder cancer
By specialty
OncologyUrology
By research site
Michael G Oefelein Clinical Trials· Bakersfield, CACarolina Urologic Research Center· Myrtle Beach, SC

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