Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study

Part of paid clinical trials in Detroit, Michigan.

Sponsor
Wayne State University
Study ID
NCT07222306
Status
Enrolling By Invitation

Conditions

  • Depressive Symptoms
  • PTSD
  • PTSD Symptoms
  • Suicidal Thoughts and Behaviors

Eligibility Criteria

Sex
ALL
Age
19 Years - 69 Years
Healthy Volunteers
Not accepted

Interventions

  • 1-(2-[+F]fluoroethyl)-L-tryptophan — DRUG
    1-(2-\[+F\]fluoroethyl)-L-tryptophan tracer will be used during PET imaging

Study Details

This study will be the first to use brain imaging to explore how cannabis affects the brain and inflammation in U.S. military veterans with PTSD. It builds on an ongoing study testing different combinations of THC and CBD in 200 veterans. In this project, up to 100 veterans will complete brain scans before and after 12 weeks of cannabis administration to see how the brain changes over time. The scans will measure a marker sensitive to neuroinflammatory state, brain communication, and activity during thinking and emotion tasks. By linking these brain changes to improvements in PTSD symptoms, suicidal thoughts, and quality of life, this study may help identify which veterans benefit most from cannabis-based treatments and support more personalized care for PTSD.

Key Dates

Start date
Nov 1, 2025
Status verified
Oct 2025
Primary completion
Aug 31, 2030
Completion
Aug 31, 2030

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: PET and/or MRI
    Positron emission tomography (PET) imaging with the radiotracer, 1-(2-\[+F\]fluoroethyl)-L-tryptophan or \[18F\]FETrp and/or magnetic resonance imaging (MRI)

Primary Outcome Measure

[18F]FETrp K-complex [ Time Frame: Baseline and follow-up (at least 12 weeks after baseline) ]

Locations (1)

FacilityCityStateZIPSite coordinators
Tolan Park Medical BuildingDetroitMichigan48201-

Find similar trials in Detroit, MI

By condition
PTSD (post-traumatic stress disorder)
By specialty
PsychiatryMental healthBehavioral health
By research site
Tolan Park Medical Building· Detroit, MI

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