Comparing Numbing Techniques in Mohs Micrographic Surgery

Conditions

• Skin Cancer Face
• Skin Cancer Scalp

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Nerve Block — OTHER
  0.45% lidocaine with 1:200,000 epinephrine
• Placebo Nerve Block — OTHER
  Sterile normal saline

Study Details

This study seeks to determine whether adjunct regional nerve blocks reduce pain and anxiety in adult patients undergoing Mohs micrographic surgery for face and scalp skin cancers. Participants will be randomized to one of two arms: (1) placebo regional nerve block with sterile normal saline or (2) adjunct regional nerve block with lidocaine. All patients receive local infiltration with lidocaine for complete anesthesia.

Key Dates

Start date

Jan 27, 2026

Status verified

May 2026

Primary completion

Jul 31, 2026

Completion

Jul 31, 2026

Study Design

Enrollment

150 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Arms

• Placebo Comparator: Placebo Nerve Block
  Placebo regional nerve block with sterile normal saline plus local anesthetic infiltration of the tumor site.
• Experimental: Regional Nerve Block
  Adjunct regional nerve block with lidocaine plus local anesthetic infiltration of the tumor site.

Primary Outcome Measure

Intraoperative Pain [ Time Frame: T1: After nerve block; T2: Immediately after completion of local infiltration but before surgical excision; T3: At the end of stage 1 of Mohs micrographic surgery. ]

Central Contacts

• Kaiyu Ma Clinical research regulatory specialist, PhD
  215-662-2123
  [email protected]
• Christopher Richter, BS
  [email protected]

Locations (1)

Find similar trials in Philadelphia, PA

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