A Clinical Study of Calderasib (MK-1084) With Rosuvastatin and Metformin in Healthy People (MK-1084-016)

Part of paid clinical trials in Lincoln, Nebraska.

Sponsor
Merck Sharp & Dohme LLC
Study ID
NCT07222098
Phase
PHASE1
Status
Completed

Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
19 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • Rosuvastatin — DRUG
    Oral tablet
  • Metformin — DRUG
    Oral tablet
  • Calderasib — DRUG
    Oral tablet

Study Details

Researchers want to learn about calderasib when given with rosuvastatin and metformin in healthy people. The goal of this study is to compare the amount of rosuvastatin and metformin in a person's body over time when given with and without calderasib

Key Dates

Start date
Nov 19, 2025
Status verified
Apr 2026
Primary completion
Dec 14, 2025
Completion
Dec 29, 2025

Study Design

Enrollment
16 participants (actual)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Rosuvastatin + metformin
    Participants will receive rosuvastatin plus metformin
  • Experimental: Rosuvastatin + metformin + Calderasib
    Participants will receive rosuvastatin plus metformin plus calderasib

Primary Outcome Measure

Area Under the Concentration-Time Curve From Time 0 to Infinity (AUC0-inf) of Rosuvastatin [ Time Frame: Day 1: Predose and at designated timepoints up to 120 hours post-dose ]

Locations (1)

FacilityCityStateZIPSite coordinators
Celerion ( Site 0001)LincolnNebraska68502-

Find similar trials in Lincoln, NE

By research site
Celerion· Lincoln, NE

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