Effect of Activated Charcoal on Serum Osmolality, Osmolal Gap, and Enzymatic Ethylene Glycol Assay
Part of paid clinical trials in Syracuse, New York.
- Sponsor
- State University of New York - Upstate Medical University
- Study ID
- NCT07220031
- Status
- Not Yet Recruiting
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Conditions
- Lab Interference
- Osmolality Disturbance
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - N/A
- Healthy Volunteers
- Accepted
Interventions
- Activated Charcoal — DRUGThis is the only intervention
Study Details
The goal of this observational study is to determine whether a clinically relevant dose of activated charcoal raises the serum osmolality and osmolal gap in a population of healthy volunteers. Secondarily to determine whether the same dose creates a false positive result using an enzymatic assay. 1. Does a clinically relevant dose of commercially available activated charcoal raise the osmolal gap above the baseline of a healthy volunteer? 2. Does the same dose of charcoal cause a false positive enzymatic assay for ethylene glycol? Participants will be asked to consume a dose of activated charcoal and have serial blood draws for laboratory measurements.
Key Dates
- Start date
- Nov 15, 2025
- Status verified
- Oct 2025
- Primary completion
- May 1, 2026
- Completion
- May 1, 2026
Study Design
- Enrollment
- 8 participants (estimated)
Arms
- Arm: CharcoalHealthy volunteers to consume activated charcoal
Primary Outcome Measure
Osmol Gap Change [ Time Frame: 6 hours ]
Central Contacts
- Vincent Calleo, MD3154646224
- Matthew Kolbeck, MD315-464-6224
Locations (1)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Upstate Medical University Clinical Research Unit | Syracuse | New York | 13210 |