Temporal Interference for Thalamocortical Activity and Network Modulation

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT07219719
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Healthy Participants

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Temporal Interference Transcranial electrical stimulation (TI-TES) — DEVICE
    TI-TES uses specific electrode arrangement patterns to selectively stimulate the brain. Participants will wear an hdEEG (high density electroencephalography) cap which will allow intermittent periods of stimulation from TI-TES.
  • Sham stimulation — DEVICE
    Sham (ramp only) stimulation will briefly ramp up and down at the beginning and end of each stimulation train, without delivering continuous stimulation throughout.

Study Details

The goal of this clinical trial is to find out whether a type of electrical brain stimulation, called temporal interference stimulation, can temporarily change the way different parts of the brain communicate with each other. Participants will: * Complete two stimulation phases - overnight and during wakefulness * Undergo two MRIs per study phase

Key Dates

Start date
Dec 1, 2025
Status verified
Apr 2026
Primary completion
May 31, 2027
Completion
Nov 30, 2027

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Stimulation
    Participants will complete two stimulation phases-overnight TI-TES during non-rapid eye movement (NREM) sleep and TI-TES during quiet wakefulness
  • Sham Comparator: Sham stimulation
    \~10 participants will be assigned to sham stimulation

Primary Outcome Measure

Change in thalamocortical functional connectivity (FC): resting state fMRI [ Time Frame: Pre- to post-intervention, up to 2 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Wisconsin - MadisonMadisonWisconsin53705
Sean Prahl
[email protected]
262-395-8675

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By research site
University of Wisconsin - Madison· Madison, WI

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