Impact of Pistachio Consumption on Sleep

Conditions

• Poor Quality Sleep

Eligibility Criteria

Sex

ALL

Age

45 Years - 64 Years

Healthy Volunteers

Accepted

Interventions

• Pistachio — DIETARY_SUPPLEMENT
  2 servings/day for 4 weeks (56 g total/day)
• Control food — DIETARY_SUPPLEMENT
  Muffins and cookies (no nuts), at an equivalent number of calories as the pistachio intervention, daily

Study Details

Sleep is essential for life and overall health. Unfortunately, a large portion of the population in the U.S. and worldwide experience sleep deficiencies, which increase their risk for developing chronic diseases. These sleep difficulties often cause distress, leading individuals to seek various forms of treatment. Given that some drugs cause habituation and undesirable side effects, individuals often turn to over-the-counter sleep remedies. However, long-term use of over-the-counter treatments is not recommended by the American Academy of Sleep Medicine for insomnia treatment and there is currently no recommendation related to dietary management. There is a strong need to identify natural measures to improve sleep in millions of adults battling poor sleep. Diet is emerging as a potentially important modulator of sleep. Despite observational data linking greater nut intake with better sleep, and that pistachios contain a significant number of sleep-promoting compounds, no study to date has evaluated the impact of pistachio supplementation on sleep. To address this key knowledge gap, the investigators propose to conduct a randomized controlled trial to evaluate the impact of pistachio consumption, relative to a calorie-matched control food, on sleep in middle-aged adults with poor sleep and to explore underlying mechanisms.

Key Dates

Start date

Dec 12, 2025

Status verified

Feb 2026

Primary completion

Aug 31, 2027

Completion

Aug 31, 2027

Study Design

Enrollment

28 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Arms

• Active Comparator: Pistachio
  During the experimental (pistachio) intervention period, participants will be given 2 servings of pistachios (28 g each) to consume once in the morning (within 3 hours of wake time) and once in the evening (3-6 hours before bedtime) every day.
• Placebo Comparator: Control
  During the control food intervention period, participants will be given muffins and cookies (one serving each/day) to be consumed once in the morning (within 3 hours of wake time) and once in the evening (3-6 hours before bedtime) every day.

Primary Outcome Measure

Self-reported sleep quality [ Time Frame: 4 weeks ]

Central Contacts

• Diane Hawkins
  347-963-8845
  [email protected]
• Joseariel Romero
  [email protected]

Locations (1)

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