Precision-Medicine Diagnostic Support in Hospitalized Veterans With Acute Kidney Injury

Part of paid clinical trials in Nashville, Tennessee.

Sponsor
VA Office of Research and Development
Study ID
NCT07217808
Status
Not Yet Recruiting

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Conditions

  • Acute Kidney Injury (AKI)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • PRECISE-AKI Clinical Decision Support Tool — OTHER
    The Intervention arm will consist of Clinical Decision Diagnostic Support (CDS) provided by the PRECISE-AKI tool

Study Details

Acute kidney injury (AKI) affects up to 20% of hospitalized Veterans and is strongly associated with morbidity and death. AKI is a diverse condition and timely and accurate diagnosis of the type of AKI is critical to begin appropriate therapies, especially those causes that require specific treatments beyond general supportive care. Yet, there are still significant gaps in the initial evaluation of AKI among hospitalized patients. Clinical decision support systems (CDSS) have shown promise to address these barriers, but most consist of simple alerting schemes and general care recommendations provided at a single point in time. The goal of this proposal is to develop and test the feasibility and usability of a rule-based and Artificial Intelligence-assisted precision CDSS tool (PRECISE-AKI) that can provide cognitive support to improve timely initial diagnostic evaluation of AKI.

Key Dates

Start date
Jan 1, 2028
Status verified
Oct 2025
Primary completion
Dec 31, 2028
Completion
Jun 30, 2029

Study Design

Enrollment
60 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • No Intervention: Control (Usual Care)
    The Control arm will consist of usual care with no additional clinical decision support tool guidance
  • Experimental: PRECISION AKI Clinical Decision Support
    The Intervention arm will consist of Clinical Decision Diagnostic Support (CDS) provided by the PRECISE-AKI tool

Primary Outcome Measure

Rates of Appropriate Diagnostic Testing [ Time Frame: Up to 30 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Tennessee Valley Healthcare System Nashville Campus, Nashville, TNNashvilleTennessee37212-2637
Michele Lenoue-Newton, PhD
[email protected]
(615) 936-6728
Edward D Siew, MD MSc (PRINCIPAL_INVESTIGATOR)
Michael E Matheny, MD MS MPH (PRINCIPAL_INVESTIGATOR)

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By research site
Tennessee Valley Healthcare System Nashville Campus, Nashville, TN· Nashville, TN

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