Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder

Part of paid clinical trials in Branford, Connecticut.

Sponsor
CND Life Sciences
Study ID
NCT07217054
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
40 Years - 99 Years
Healthy Volunteers
Not accepted

Study Details

The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). The main question it aims to answer is: Can doctors find a protein called alpha-synuclein in colon tissue samples from people with Parkinson's disease and RBD? Currently, Parkinson's disease is diagnosed by observing symptoms like tremors and movement problems and RBD by loss of muscle atonia during REM sleep, but by then the disease has already progressed significantly. Earlier detection could help doctors start treatment sooner.

Key Dates

Start date
Nov 4, 2025
Status verified
Feb 2026
Primary completion
Oct 31, 2028
Completion
Oct 31, 2029

Study Design

Enrollment
40 participants (estimated)

Arms

  • Arm: Parkinson's Disease (PD)
    Trial participants with Parkinson's disease
  • Arm: REM Sleep Behavior Disorder (RBD)
    Trial participants with REM Sleep Behavior Disorder (RBD)

Primary Outcome Measure

Detection of phosphorylated alpha-synuclein in colon tissue samples [ Time Frame: At time of colonoscopy procedure ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Digestive Disease AssociatesBranfordConnecticut06405
Christina Wagner
[email protected]
203-481-0315
Daniel J Zanchetti, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Branford, CT

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
Digestive Disease Associates· Branford, CT

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