The Erector Spinae Plane Block For Gastrointestinal Malignancy Pain Treatment (EGIPT)

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
Abramson Cancer Center at Penn Medicine
Study ID
NCT07211386
Status
Recruiting
Apply to this trial

Conditions

  • Gastrointestinal Malignancy
  • Pain Control

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Erector Spinae Plane Block — PROCEDURE
    The abdominal viscera, from the stomach to midway through the sigmoid colon, derives its sensory innervation from afferent fibers that travel with, but are distinct from, the sympathetic nerve fibers from the 5th thoracic (T5) to the 2nd lumbar (L2) spinal levels (Moore et al). These fibers converge at the celiac plexus, located near the celiac artery and the aorta. From there, they bifurcate into the paravertebral sympathetic chain and subsequently ascend to the spinal cord and integrate into the central nervous system (Lohse et al). The celiac plexus block is an invasive procedure performed by an interventional anesthesiologist or palliative care specialist to lyse the celiac plexus and has been shown to reduce pain and opiate use in patients suffering from GI malignancy (Ashlock et al). While there are multiple methods to perform a celiac plexus block, it involves a steep needle trajectory either posteriorly through the retroperitoneum or anteriorly through the abdominal wall close

Study Details

This study will target patients with gastrointestinal (GI) malignancy who present to any of 4 Penn Medicine emergency departments (EDs) with intractable abdominal pain. We will offer eligible patients an erector spinae plane block (ESPB), a regional anesthesia technique which is already offered to such patients in the ED at the University of Pennsylvania Healthy System (UPHS), for their intractable abdominal pain. We will compare the outcomes of this prospective cohort of patients to a matched historical control of patients with GI malignancy who were treated in the ED during the same time period as recruitment, but who were not recruited to partake in the study and who were managed with standard of care. Opioid consumption as measured by total milligram morphine equivalents (MMEs) over a 24-hour period and hospital length of stay (LOS) will be compared between cohorts. Additionally, for the ESPB cohort, pain level pre/post ESPB, and functionality and satisfaction with pain management at 24 hours will also be examined.

Key Dates

Start date
Dec 11, 2025
Status verified
Nov 2025
Primary completion
May 15, 2027
Completion
Jun 15, 2027

Study Design

Enrollment
25 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment Arm -- Erector Spinae Plane Block
    Patients with gastrointestinal malignancy and abdominal pain will receive the erector spinae plane block for their abdominal pain.

Primary Outcome Measure

Opioid Consumption [ Time Frame: 24 hours ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
Hospital of the University of PennsylvaniaPhiladelphiaPennsylvania19104
Umar Aulia, AB
[email protected]
267-624-4394
Hospital of the University of Pennsylvania -- Cedar AvenuePhiladelphiaPennsylvania19143
Umar Aulia, AB
[email protected]
267-624-4394
Penn Presbyterian Medical CenterPhiladelphiaPennsylvania19104
Umar Aulia, AB
[email protected]
267-624-4394
Pennsylvania HospitalPhiladelphiaPennsylvania19107
Umar Aulia, AB
[email protected]
267-624-4394

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By research site
Hospital of the University of Pennsylvania· Philadelphia, PAHospital of the University of Pennsylvania -- Cedar Avenue· Philadelphia, PAPenn Presbyterian Medical Center· Philadelphia, PAPennsylvania Hospital· Philadelphia, PA

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