A Study of Elacestrant Alone or in Combination With Abemaciclib in People With Endometrial Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07209449
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Abemaciclib — DRUG
    orally only in the evening
  • Elacestrant — DRUG
    orally once daily in the morning

Study Details

The researchers are doing this study to find out whether elacestrant is an effective and safe treatment alone or in combination with abemaciclib for people with advanced or recurrent ER+ endometrial cancer.

Key Dates

Start date
Oct 1, 2025
Status verified
Jun 2026
Primary completion
Oct 1, 2028
Completion
Oct 1, 2028

Study Design

Enrollment
75 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Abemaciclib plus Elacestrant
    Patients receiving both drugs should take elacestrant orally once daily with abemaciclib orally in the morning and abemaciclib orally only in the evening at the same time every day.
  • Experimental: Elacestrant alone
    Patients receiving elacestrant only should take orally once daily in the morning.

Primary Outcome Measure

objective response rate [ Time Frame: 1 year ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking RidgeBasking RidgeNew Jersey07920
Sminu Bose, MD
646-888-5427
Memorial Sloan Kettering MonmouthMiddletownNew Jersey07748
Sminu Bose, MD
646-888-5427
Memorial Sloan Kettering BergenMontvaleNew Jersey07645
Sminu Bose, MD
646-888-5427
Memorial Sloan Kettering CommackCommackNew York11725
Sminu Bose, MD
646-888-5427
Memorial Sloan Kettering WestchesterHarrisonNew York10604
Sminu Bose, MD
646-888-5427
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Sminu Bose, MD
646-888-5427
Memorial Sloan Kettering NassauUniondaleNew York11553
Sminu Bose, MD
646-888-5427

Find similar trials in Basking Ridge, NJ

By condition
Endometrial cancer
By specialty
OncologyGynecologic oncologyWomen's health
By research site
Memorial Sloan Kettering Basking Ridge· Basking Ridge, NJMemorial Sloan Kettering Monmouth· Middletown, NJMemorial Sloan Kettering Bergen· Montvale, NJMemorial Sloan Kettering Commack· Commack, NYMemorial Sloan Kettering Westchester· Harrison, NYMemorial Sloan Kettering Cancer Center· New York, NY

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