Fructose Intestinal Gluconeogenesis

Part of paid clinical trials in Vallejo, California.

Sponsor
Touro University, California
Study ID
NCT07209202
Status
Recruiting
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Conditions

  • Healthy Participants
  • Obese But Otherwise Healthy Participants

Eligibility Criteria

Sex
ALL
Age
20 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • High fructose meal — OTHER
    Liquid meals containing 55% total carbohydrate (16% fructose), 30% fat, 15% protein.
  • Low fructose meal — OTHER
    55% total carbohydrate (6% fructose), 30% fat, 15% protein.
  • 13C labeled fructose, oral — OTHER
    Tracer amount of 13C labeled fructose administered orally in the meals.
  • 13C labeled fructose, intravenous — OTHER
    Tracer amount of 13C fructose administered intravenously

Study Details

This study will test the hypothesis that within a defined range of fructose intake, the ability to convert fructose to glucose (via gluconeogenesis) in the small intestine plays a protective role for the liver, shielding it from the deleterious effects of fructose. We will investigate whether this protective effect of the intestine is impaired in individuals with obesity.

Key Dates

Start date
Mar 2, 2026
Status verified
Mar 2026
Primary completion
Jun 30, 2030
Completion
Jun 30, 2030

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: High fructose meals, oral 13C fructose
    Liquid meals will be fed, containing 55% total carbohydrate (16% fructose), 30% fat, 15% protein, and a tracer amount of 13C fructose.
  • Experimental: High Fructose Meals, IV 13C Fructose
    Liquid meals will be fed, containing 55% total carbohydrate (16% fructose), 30% fat, 15% protein. A tracer amount of 13C fructose will be administered intravenously.
  • Experimental: Low fructose meals, oral fructose tracer
    Liquid meals will be fed, containing 55% total carbohydrate (6% fructose), 30% fat, 15% protein, and a tracer amount of 13C fructose.
  • Experimental: Low fructose meals, IV 13C fructose tracer
    Liquid meals will be fed, containing 55% total carbohydrate (6% fructose), 30% fat, 15% protein. A tracer amount of 13C fructose will be administered intravenously.

Primary Outcome Measure

Fru-GNG [ Time Frame: 6 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Touro University CaliforniaVallejoCalifornia95492
Sally Chiu, PhD
[email protected]

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Touro University California· Vallejo, CA

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