A Study to Investigate the Safety and Efficacy of KQB548 in Participants With Advanced Solid Malignancies

Part of paid clinical trials in La Jolla, California.

Sponsor
Kumquat Biosciences Inc.
Study ID
NCT07207707
Phase
PHASE1
Status
Recruiting
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Conditions

  • Solid Tumor Malignancies

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • KQB548 — DRUG
    Oral KQB548

Study Details

The goal of this trial is to learn if KQB548 works to treat patients with advanced solid malignancies with a KRAS G12D mutation. It will also learn about the safety of KQB548. The main questions it aims to answer are: * What is the safe dose of KQB548? * Does KQB548 decrease the size of the tumor? * What happens to KQB548 in the body?

Key Dates

Start date
Sep 16, 2025
Status verified
Mar 2026
Primary completion
Sep 30, 2026
Completion
Mar 31, 2027

Study Design

Enrollment
78 participants (estimated)
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Monotherapy Dose Escalation

Primary Outcome Measure

Safety,Tolerability, MTD/MAD and/or RDE in the Study Population [ Time Frame: Up to 30 months ]

Central Contacts

Locations (13)

FacilityCityStateZIPSite coordinators
University of California, San DiegoLa JollaCalifornia92037-
University of California, Los AngelesLos AngelesCalifornia90095-
SCRI - DenverDenverColorado80218-
University of Miami - Sylvester Comprehensive Cancer CenterMiamiFlorida33136-
START MidwestGrand RapidsMichigan49546-
The Christ HospitalCincinnatiOhio45219-
NEXT Oncology - AustinAustinTexas78758-
MD Anderson Cancer CenterHoustonTexas77030-
NEXT Oncology - DallasIrvingTexas75039-
NEXT Oncology - San AntonioSan AntonioTexas78229-
University of Utah - Huntsman Cancer InstituteSalt Lake CityUtah84112-
NEXT VirginiaFairfaxVirginia22031-
Fred Hutchison Cancer CenterSeattleWashington98195-

Find similar trials in La Jolla, CA

By research site
University of California, San Diego· La Jolla, CAUniversity of California, Los Angeles· Los Angeles, CASCRI - Denver· Denver, COUniversity of Miami - Sylvester Comprehensive Cancer Center· Miami, FLSTART Midwest· Grand Rapids, MIThe Christ Hospital· Cincinnati, OH

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