Treatment of Borderline Personality Disorder With rTMS

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT07197502
Status
Recruiting
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Conditions

  • BPD - Borderline Personality Disorder
  • Borderline Personality
  • Borderline Personality Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Magnetic Stimulation (TMS) — DEVICE
    Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve symptoms of depression. Using pulsed magnetic fields, transcranial magnetic stimulation therapy stimulates the part of the brain thought to be involved with mood regulation. These magnetic fields do not directly affect the whole brain; they only reach about 2-3 centimeters into the brain directly beneath the treatment coil.As these magnetic fields move into the brain, they produce very small electrical currents. These electrical currents activate cells within the brain, causing them to rewire, a process called neuroplasticity.

Study Details

This project studies the effectiveness of brain stimulation on borderline personality disorder (BPD) symptoms. This study is blinded, randomized and will enroll up to 30 participants. Participant will be consented for the study remotely via a secure internet platform called Zoom. Participants will undergo up to 2 MRI scans, 2 brain wave recording sessions and up to 30 brain stimulation treatments, and complete symptom assessments and cognitive behavioral tasks on a computer. Participation requires minimum of 17 in person visits over the course of 2.5 months. Participants are randomly assigned active or sham brain stimulation. Participants who received sham brain stimulation have the option to receive additional 15 active brain stimulation session.

Key Dates

Start date
Mar 1, 2025
Status verified
Sep 2025
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Active
    Subjects in this group will receive active TMS treatment at vlPFC delivered by a magnet called A/P (active/placebo) coil. The A/P coil supports double-blinding of treatment. The coil has two sides, one of which is shielded so that no energy is imparted to the brain when the shielded side is applied to the subject's head. Small skin electrodes are applied to the scalp under the coil that impart a small microcurrent to the scalp simulating the sensation of active treatment. The operator receives a code from the device instructing them which side of the coil to use for each subject, ensuring complete treatment blinding.
  • Experimental: Sham- followed by Active treatment
    Patients will be randomized to receive active or sham at vlPFC. Subjects assigned to the sham-controlled condition will be offered the opportunity to cross-over to open - label TMS treatment at the conclusion of the double-blind phase. This phase will serve as an incentive to recruitment because it ensures that all subjects (even those initially receiving sham stimulation) will eventually be eligible to receive active treatment. Rating scale scores will be obtained in the open-label extension just as scheduled in the controlled phase to gather additional information on efficacy of the active intervention.

Primary Outcome Measure

Borderline Symptom List 23 (BSL-23) [ Time Frame: Baseline (Day 1) and Post treatment (Day 17) ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Semel Institute for Neuroscience and Human Behavior at UCLALos AngelesCalifornia90024
Elizabeth Pinkerton
[email protected]
310-794-0331
Research Coordinator
[email protected]
Semel Institute/ UCLA TMSLos AngelesCalifornia90024
Elizabeth Pinkerton, BS
[email protected]
310-794-0331
UCLA TMS Research Coordinator
[email protected]
Andrew Leuchter, MD (PRINCIPAL_INVESTIGATOR)
Reza Tadayon-Nejad, MD, PhD (SUB_INVESTIGATOR)

Find similar trials in Los Angeles, CA

By research site
Semel Institute for Neuroscience and Human Behavior at UCLA· Los Angeles, CASemel Institute/ UCLA TMS· Los Angeles, CA

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