Initial Study Sesting Efficacy and Tolerability of PT150 for PTSD in Veterans

Part of paid clinical trials in San Diego, California.

Sponsor
San Diego Veterans Healthcare System
Study ID
NCT07187011
Phase
PHASE2
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

  • PTSD - Post Traumatic Stress Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • PT150 — DRUG
    Glucorticoid antagonist 900 mg
  • Placebo — DRUG
    900 mg

Study Details

The purpose of this study is to test the drug PT150, which blocks glucocorticoid receptor (GR) signaling, for treatment of PTSD in Veterans, and establish a safety and efficacy profile that will inform the design of future studies.

Key Dates

Start date
Apr 1, 2026
Status verified
Dec 2025
Primary completion
Mar 1, 2029
Completion
May 1, 2029

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: Placebo
    Placebo
  • Experimental: PT150
    150-900 mg study drug dose titrated over 7 days

Primary Outcome Measure

PTSD Symptoms - Clinician Administered PTSD Scale for DSM-5 (CAPS) [ Time Frame: approximately 4 weeks ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Jennifer Moreno Department of VA Medical CenterSan DiegoCalifornia92161-
Michael E DeBakey VA Medical CenterHoustonTexas77030-

Find similar trials in San Diego, CA

By research site
Jennifer Moreno Department of VA Medical Center· San Diego, CAMichael E DeBakey VA Medical Center· Houston, TX

Related Studies