Ketorolac Use and Fresh Embryo Transfer Outcomes

Part of paid clinical trials in Iowa City, Iowa.

Sponsor
Jessica D. Kresowik
Study ID
NCT07185724
Phase
PHASE4
Status
Recruiting
Apply to this trial

Conditions

  • Fresh Embryo Transfer
  • Infertility (IVF Patients)
  • Infertility Treatment
  • Oocyte Retrieval and Post Operative Pain Control
  • Post-op Pain

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 37 Years
Healthy Volunteers
Not accepted

Interventions

  • Ketorolac 30 mg IV — DRUG
    We will be evaluating the effect of post-oocyte retrieval ketorolac administration on clinical outcomes in fresh embryo transfer cycles.

Study Details

Ketorolac is a medication often used to relieve pain after surgery. In the past, infertility doctors have been cautious about using ketorolac after egg retrieval for patients planning a fresh embryo transfer (usually done 5 days later). The concern was that ketorolac might increase the risk of bleeding or reduce the chances of the embryo implanting in the uterus. This concern comes from how ketorolac works-it blocks certain chemicals in the body (like prostaglandins and thromboxane) that help with blood clotting and play a role in early pregnancy. However, a large review of past studies found no real evidence that ketorolac increases bleeding risk. In fact, ketorolac is now routinely used for pain relief in IVF cycles where embryos are frozen and not transferred right away. More recent studies from Boston and Chapel Hill have shown that ketorolac provides better pain control and does not appear to harm IVF outcomes, even when embryos are transferred fresh (within the same cycle). Despite these encouraging findings, many IVF clinics still avoid using ketorolac during fresh cycles because of the theoretical concerns. That's why we need stronger, higher-quality research. This study aims to fill that gap by conducting a double-blind randomized controlled trial to find out whether giving ketorolac through an IV after egg retrieval affects important IVF outcomes-especially the chance of implantation and live birth-in patients undergoing fresh embryo transfers. Patients who choose to join the study will randomly be placed into one of two groups. One group will get ketorolac (a pain medicine) after an IVF egg retrieval. The other group will not get ketorolac after egg retrieval. Everything else in their IVF care will stay the same as it normally would. Primary outcome will be implantation rate following fresh embryo transfers in patients receiving ketorolac (30mg IV) vs no ketorolac for post-retrieval analgesia. Secondary outcomes will include pain scale, narcotics required, time to discharge, need for evaluation w/in 24 hours for pain/bleeding, clinical pregnancy rates, miscarriage rates, and live birth rates following fresh embryo transfers in patients receiving ketorolac vs no ketorolac for post-retrieval analgesia.

Key Dates

Start date
Nov 8, 2025
Status verified
Dec 2025
Primary completion
Oct 1, 2027
Completion
Sep 1, 2028

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: IV Ketorolac
    Participants randomized to this arm will receive 30mg IV Ketorolac at the conclusion of their oocyte retrieval.
  • No Intervention: No IV Ketorolac
    Participants randomized to this arm will not receive IV Ketorolac at the conclusion of their oocyte retrieval.

Primary Outcome Measure

Implantation Rate [ Time Frame: From enrollment to the time of confirmation of pregnancy ultrasound at ~6 weeks post-oocyte retrieval (with or without administration of IV Ketorolac) . ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UI Health Care Center for Advanced Reproductive CareIowa CityIowa52245
Aya Iwamoto, MD
[email protected]
(319) 356-1767
Jessica Kresowik (PRINCIPAL_INVESTIGATOR)
Aya Iwamoto (SUB_INVESTIGATOR)
Hakan Duran (SUB_INVESTIGATOR)
Abey Eapen (SUB_INVESTIGATOR)
Abigail Mancuso (SUB_INVESTIGATOR)
Salomeh Salari (SUB_INVESTIGATOR)
Melissa Mathes (SUB_INVESTIGATOR)

Find similar trials in Iowa City, IA

By research site
UI Health Care Center for Advanced Reproductive Care· Iowa City, IA

Related Studies