Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)

Part of paid clinical trials in Charlottesville, Virginia.

Sponsor
University of Virginia
Study ID
NCT07182955
Status
Recruiting
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Conditions

  • Atherosclerotic Heart Disease of Native Coronary Artery
  • MINOCA
  • Shortness of Breath

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • EXERCISE TRAINING WITH OR WITHOUT MEDICATION — BEHAVIORAL
    Remote 4 weeks of high-intensity interval exercise training on three non-consecutive days of the week.

Study Details

The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it. This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life. Investigators also want to see if a structured high-intensity exercise program (HIIT), done with remote monitoring, can safely improve heart function, fitness, and quality of life in these patients. The Investigators will use a special exercise test called cardiopulmonary exercise testing to look for patterns that can help explain exercise limitations and quality of life in ANOCA before and after a remote high-intensity exercise program.

Key Dates

Start date
Aug 11, 2025
Status verified
Sep 2025
Primary completion
Mar 30, 2026
Completion
Apr 14, 2026

Study Design

Enrollment
25 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Experimental: Exercise
    Remote 4 weeks of high-intensity interval exercise training on three non-consecutive days of the week.

Primary Outcome Measure

Examine cardiorespiratory fitness (change in VO2max in mL/kg/min) with cardiopulmonary exercise testing (CPET) Phenotype. [ Time Frame: 4 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Virginia Health SystemCharlottesvilleVirginia22908
Rahel Askari
[email protected]
434-243-7195
Jamieson M Bourque, MD, MHS (PRINCIPAL_INVESTIGATOR)

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By research site
University of Virginia Health System· Charlottesville, VA

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