SGLT2 Inhibitors in Geographic Atrophy

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT07174687
Phase
PHASE2
Status
Recruiting
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Conditions

  • Eye Diseases
  • Geographic Atrophy
  • Pathological Conditions, Anatomical
  • Retinal Degeneration
  • Retinal Diseases

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Dapagliflozin — DRUG
    Dapagliflozin is an SGLT2 inhibitor used in diabetes, heart failure, and chronic kidney disease patients.
  • Matching Placebo — OTHER
    Matching oral placebo to dapagliflozin

Study Details

AMD is a leading cause of blindness in individuals over 50 years old, with dry AMD being the most common form. Geographic atrophy (GA) is an advanced stage of dry AMD characterized by progressive retinal cell degeneration. The primary objectives of the study are to assess the safety, tolerability, and evidence of activity of SGLT2 inhibitors in subjects with Geographic Atrophy associated with AMD.

Key Dates

Start date
Dec 2, 2025
Status verified
Dec 2025
Primary completion
Dec 31, 2027
Completion
Jun 30, 2028

Study Design

Enrollment
70 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Dapagliflozin 10 mg daily for 12 months
    Dapagliflozin 10 mg daily PO for 12 consecutive months
  • Placebo Comparator: Matching Placebo for 12 months
    Subjects will receive a placebo medication daily PO for 12 consecutive months

Primary Outcome Measure

Mean Change From Baseline in Square Root GA Lesion Size in the Study Eye at Month 12 [ Time Frame: Baseline (screening) and Month 12. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Washington UniversitySt LouisMissouri63110
Eve Adcock
[email protected]
314-286-2946
Rajendra S Apte, MD PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in St Louis, MO

By condition
Age-related macular degeneration
By specialty
OphthalmologyRetina
By research site
Washington University· St Louis, MO

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