Remote Evaluation and Alerting for Collaborative Health (REACH) in Depression

Conditions

• Depression
• Major Depressive Disorder

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• MoodTriggers Application — OTHER
  The Mood Triggers application, developed by Dr. Jacobson, will be used for collecting smartphone sensor data. This HIPAA-compliant app has been incorporated into various projects at Dartmouth, Stanford, and MGH/Harvard, with development supported by NIDA, NIMHD, NCI, and the Department of Veterans Affairs. The Mood Triggers app will capture a wide range of metrics, including psychomotor agitation, sleep disturbances, low behavioral activation, social contact, exposure to natural light, heart rate, heart rate variability, and screen time. The app also tracks the patient's screen time and app usage data. The Mood Triggers App will be installed on the smartphones at time of informed consent for all 120 patients enrolled in Phase 1 and for 100 clinical trial participants randomized to the "early warning system" (intervention arm) in Phase 2. Data will be collected from the Mood Triggers App starting on day of discharge from care and for 6 months post-discharge date.

Study Details

Researchers hope to see if the data smartphones collect continuously can be used to predict if patient's depression symptoms will return. They will do this by collecting data from patient's smartphones and comparing it to their depression symptoms. If this method is successful, researchers could develop a smartphone application to help healthcare providers better monitor patient's depression and intervene earlier if symptoms return.

Key Dates

Start date

Jan 1, 2026

Status verified

Dec 2025

Primary completion

Nov 1, 2029

Completion

Nov 1, 2029

Study Design

Enrollment

320 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Arms

• Experimental: Phase 1: Sensing System Calibration (N = 120)
  We expect that participants will be in this research study for six months. Participants will be asked to download an app on their smartphone. This app will collect data from the phone's sensors. Participants will also be asked to answer some questions about their mood each month.
• Active Comparator: Phase 2: Early warning system (n = 100)
  This study is randomized which means that in order to learn about the effect of the Smartphone App, half the people in this study will use it, and the other half will not. If participants decide to enroll into this research study, they may be assigned by chance to download a Smartphone App. This App will collect data from the phone's sensors. Participants will also be asked to complete questionnaires about their mood each month.
• No Intervention: Phase 2: Usual Care (n = 100)
  This study is randomized which means that in order to learn about the effect of the Smartphone App, half the people in this study will use it, and the other half will not. If participants decide to enroll into this research study, they may be assigned by chance to have usual care. Participants will be asked to complete questionnaires about their mood each month.

Primary Outcome Measure

Monthly depression relapse [ Time Frame: discharge, 6-months post-discharge ]

Central Contacts

• Nicholas C Jacobson, PhD
  (603) 646-7037
  [email protected]

Locations (2)

Find similar trials in Hanover, NH

Related Studies

• Internet Based Psychological Support
  Recruiting · Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire
• Evaluating the Impact of Psychotherapeutic Advertising Claims on Cannabis Purchasing
  Recruiting · Trustees of Dartmouth College · Lebanon, New Hampshire
• Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
  PHASE2 · Recruiting · National Institute of Mental Health (NIMH) · Bethesda, Maryland
• Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
  Recruiting · National Institute of Mental Health (NIMH) · Bethesda, Maryland