IH, Brain Health, and T2D

Part of paid clinical trials in Iowa City, Iowa.

Sponsor
Darren P Casey
Study ID
NCT07173543
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
60 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Intermittent Hypoxia 1 (IH1) — OTHER
    Intermittent Hypoxia 1 (IH1): 5 cycles of normoxia (4 minutes)/hypoxia (6 minutes) per session. 3 sessions per week for 8 weeks
  • Intermittent Hypoxia 2 (IH2) — OTHER
    Intermittent Hypoxia 1 (IH2): 5 cycles of normoxia (4 minutes)/hypoxia (6 minutes) per session. 3 sessions per week for 4 weeks
  • SHAM - normoxia — OTHER
    Participants will receive normoxia (no hypoxia) over 50 minutes.

Study Details

The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).

Key Dates

Start date
Sep 22, 2025
Status verified
Mar 2026
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Intermittent Hypoxia 1
    Participants will receive intermittent hypoxia (5 cycles of normoxia/hypoxia over 50 minutes).
  • Sham Comparator: Normoxia
    Participants will receive normoxia over 50 minutes.
  • Experimental: Intermittent Hypoxia 2
    Participants will receive intermittent hypoxia (5 cycles of normoxia/hypoxia over 50 minutes).

Primary Outcome Measure

Internal Carotid Artery (ICA) shear-mediated dilation [ Time Frame: Baseline and post 2-,4-,5-,6-, and 8-weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of IowaIowa CityIowa52242
Darren P Casey, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Iowa City, IA

By condition
Type 2 diabetes
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
University of Iowa· Iowa City, IA

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