[18F]-AraG PET Imaging in LA HNSCC

Part of paid clinical trials in Indianapolis, Indiana.

Sponsor
Indiana University
Study ID
NCT07168785
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Head and Neck Squamous Cell Carcinoma (HNSCC)
  • Locally Advanced Head and Neck Squamous Cell Carcinoma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • [18F]-AraG radiotracer — DRUG
    \[18F\]-AraG radiotracer, which occurs on the first and sixteenth day of treatment.
  • Chemotherapy — DRUG
    Concurrent chemoradiotherapy (CRT) with weekly doses of cisplatin.
  • Radiotherapy — DEVICE
    Concurrent chemoradiotherapy (CRT) of 70Gy of radiation dose in 33 fractions.

Study Details

This study will use \[18F\]-AraG PET/CT scans to monitor patients who have been diagnosed with locally advanced Head and Neck Squamous Cell carcinoma (LA-HNSCC), and are planning to undergo standard of care chemoradiotherapy for treatment.

Key Dates

Start date
Oct 1, 2025
Status verified
Sep 2025
Primary completion
Jun 30, 2027
Completion
Oct 31, 2027

Study Design

Enrollment
5 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: [18F]-AraG PET/CT scan
    \[18F\]-AraG PET/CT scans to be performed according to the institution's standard of operation, which occurs on the first and sixteenth day of treatment.

Primary Outcome Measure

[18F]-AraG PET/CT uptake and infiltrating cytotoxic T-cell expression. [ Time Frame: Week 1 and Week 16 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Indiana UniversityIndianapolisIndiana46202
Kathryn I Lauer
[email protected]
(317) 962-8969
Mark Langer, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Indiana University· Indianapolis, IN

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