A Study of ZW251 in Participants With Advanced Solid Tumors

Part of paid clinical trials in San Francisco, California.

Sponsor
Zymeworks BC Inc.
Study ID
NCT07164313
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • ZW251 — DRUG
    Administered intravenously

Study Details

The purpose of this study is to find out if ZW251, an antibody-drug conjugate targeting glypican-3 (GPC3), is safe and can treat participants with advanced cancers, including hepatocellular carcinoma (HCC), squamous cell non-small cell lung cancer (NSCLC), or germ cell tumors (GCT).

Key Dates

Start date
Oct 21, 2025
Status verified
May 2026
Primary completion
Sep 30, 2027
Completion
May 31, 2028

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: ZW251

Primary Outcome Measure

Incidence of dose-limiting toxicities (DLTs; Part 1) [ Time Frame: Up to 3 weeks ]

Central Contacts

Locations (8)

FacilityCityStateZIPSite coordinators
UCSF Comprehensive Cancer CenterSan FranciscoCalifornia94158
Katie Kelley, MD (PRINCIPAL_INVESTIGATOR)
University of California Los Angeles - Cancer Care - Santa Monica (UCLA)Santa MonicaCalifornia90404
Richard Finn, MD (PRINCIPAL_INVESTIGATOR)
Norton Cancer InstituteLouisvilleKentucky40202
John Hamm, MD FACP, FASCO (PRINCIPAL_INVESTIGATOR)
START MidwestGrand RapidsMichigan49546
Sreenivasa Chandana, MD, PhD (PRINCIPAL_INVESTIGATOR)
Hackensack University Medical CenterHackensackNew Jersey07601
Martin Gutierrez, MD (PRINCIPAL_INVESTIGATOR)
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065-6800
Ghassan Abou-Alfa, MD, JD, MBA, PhD (PRINCIPAL_INVESTIGATOR)
MD Anderson Cancer CenterHoustonTexas77030
Ecaterina Dumbrava, MD (PRINCIPAL_INVESTIGATOR)
START San AntonioSan AntonioTexas78229
Muralidhar Beeram, MD, MBBS (PRINCIPAL_INVESTIGATOR)

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UCSF Comprehensive Cancer Center· San Francisco, CAUniversity of California Los Angeles - Cancer Care - Santa Monica (UCLA)· Santa Monica, CANorton Cancer Institute· Louisville, KYSTART Midwest· Grand Rapids, MIHackensack University Medical Center· Hackensack, NJMemorial Sloan Kettering Cancer Center· New York, NY

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