Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
Mayo Clinic
Study ID
NCT07164131
Phase
PHASE4
Status
Recruiting
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Conditions

  • Community-acquired Pneumonia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Doxycycline — DRUG
    Subjects will receive Doxycycline (orally or intravenously) in combination with beta-lactam therapy within 12 hours of hospital admission. Treatment duration will be 5-7 days.
  • Azithromycin — DRUG
    Subjects will receive Azithromycin (orally or intravenously) in combination with beta-lactam therapy within 12 hours of hospital admission. Treatment duration will be 5-7 days.

Study Details

The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.

Key Dates

Start date
Sep 15, 2025
Status verified
Sep 2025
Primary completion
Sep 1, 2030
Completion
Sep 1, 2031

Study Design

Enrollment
1,120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Doxycycline group
    Subjects hospitalized for community acquired pneumonia will receive standard of care treatment with Doxycycline
  • Active Comparator: Azithromycin group
    Subjects hospitalized for community acquired pneumonia will receive standard of care treatment with Azithromycin

Primary Outcome Measure

Hospital-free days [ Time Frame: 28 days ]

Locations (5)

FacilityCityStateZIPSite coordinators
Mayo Clinic in ArizonaScottsdaleArizona85259
Cyril Varghese (PRINCIPAL_INVESTIGATOR)
Mayo Clinic in FloridaJacksonvilleFlorida32224
Swetha Reddy (PRINCIPAL_INVESTIGATOR)
Mayo Clinic Health System-MankatoMankatoMinnesota56001
Mohamad El Labban (PRINCIPAL_INVESTIGATOR)
Mayo Clinic in RochesterRochesterMinnesota55905
Amy Amsbaugh
[email protected]
507-538-7538
Yewande Efunpeju Odeyemi (PRINCIPAL_INVESTIGATOR)
Mayo Clinic Health System-La CrosseLa CrosseWisconsin54601
Melissa K Myers (PRINCIPAL_INVESTIGATOR)

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Mayo Clinic in Arizona· Scottsdale, AZMayo Clinic in Florida· Jacksonville, FLMayo Clinic Health System-Mankato· Mankato, MNMayo Clinic in Rochester· Rochester, MNMayo Clinic Health System-La Crosse· La Crosse, WI

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