A Phase 1/2a, First-in-human, Study of BMS-986517 in Participants With Advanced Solid Tumors

Part of paid clinical trials in Irvine, California.

Sponsor
Bristol-Myers Squibb
Study ID
NCT07160725
Phase
PHASE1/PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Solid Tumours

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • BMS-986517 — DRUG
    Specified dose on specified days

Study Details

A phase 1/2a, open-label, first-in-human study mainly aimed to evaluate the safety and tolerability of BMS-986517 in participants with solid tumors

Key Dates

Start date
Oct 15, 2025
Status verified
May 2026
Primary completion
Jul 31, 2028
Completion
Aug 1, 2028

Study Design

Enrollment
315 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Part 1
  • Experimental: Part 2: Cohort A
  • Experimental: Part 2: Cohort B
  • Experimental: Part 2: Cohort C

Primary Outcome Measure

Number of Participants with Adverse Events (AE) [ Time Frame: Up to approximately 2 years ]

Central Contacts

  • BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
    855-907-3286
    [email protected]
  • First line of the email MUST contain NCT # and Site #.

Locations (9)

FacilityCityStateZIPSite coordinators
Local Institution - 0033IrvineCalifornia92612
Site 0033
USC/Norris Comprehensive Cancer CenterLos AngelesCalifornia90033
Anthony El-Khoueiry, Site 0002
323-865-3967
University of California, Irvine (UCI) Health - UC Irvine Medical CenterOrangeCalifornia92868-3201
Rupali Nabar, Site 0021
310-222-2222
UPMC Hillman Cancer CenterPittsburghPennsylvania15232
Dan Zandberg, Site 0008
412-864-7955
Sanford Cancer CenterSioux FallsSouth Dakota57104
Steven Powell, Site 0005
605-328-8000
START - Dallas Fort WorthFort WorthTexas76104
Henry Xiong, Site 0030
682-350-3010
START San AntonioSan AntonioTexas78229
Drew Rasco, Site 0020
210-593-5250
START Mountain RegionWest Valley CityUtah84119
William McKean, Site 0031
801-907-4750
Fred Hutchinson Cancer CenterSeattleWashington98109
Lauren Shih, Site 0028
206-606-7763

Find similar trials in Irvine, CA

By research site
Local Institution - 0033· Irvine, CAUSC/Norris Comprehensive Cancer Center· Los Angeles, CAUniversity of California, Irvine (UCI) Health - UC Irvine Medical Center· Orange, CAUPMC Hillman Cancer Center· Pittsburgh, PASanford Cancer Center· Sioux Falls, SDSTART - Dallas Fort Worth· Fort Worth, TX

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