Neurofeedback to Treat Depression - 2

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT07159061
Status
Recruiting
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Conditions

  • Major Depressive Disorder (MDD)

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Active Closed Loop Real Time fMRI Neurofeedback — BEHAVIORAL
    Active neurofeedback to target neural mechanisms underlying attentional bias in participants with major depressive discover (MDD)
  • Sham Closed Loop Real Time fMRI Neurofeedback — BEHAVIORAL
    Sham (placebo) neurofeedback to target neural mechanisms underlying attentional bias in participants with major depressive discover (MDD)

Study Details

This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD. This real-time fMRI neurofeedback therapy uses cloud-based pattern classification to decode a patient's attentional state and dynamically modulate task stimuli (in a closed loop) based on this state.

Key Dates

Start date
Nov 21, 2025
Status verified
Dec 2025
Primary completion
Nov 21, 2028
Completion
Dec 1, 2028

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Active Comparator: Active Neurofeedback
    R33 Phase: Three training sessions. Each training session contains 32 minutes of active neurofeedback runs.
  • Sham Comparator: Sham Comparator: Sham Neurofeedback
    R33 Phase: Three training sessions. Each training session contains 32 minutes of sham (placebo) neurofeedback runs.

Primary Outcome Measure

Montgomery Asberg Depression Rating Scale (MADRS) [ Time Frame: 3 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Neuromodulation in Depression and StressPhiladelphiaPennsylvania19104
Maria Prociuk
[email protected]
(215) 573-4229
Yvette Sheline, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Philadelphia, PA

By research site
Center for Neuromodulation in Depression and Stress· Philadelphia, PA

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