Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
University of Minnesota
Study ID
NCT07158853
Status
Recruiting
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Conditions

  • Buprenorphine
  • Opioid Use Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Direct Current Stimulation (tDCS) — DEVICE
    We will deliver 2-mA tDCS current intensity during a 30 minute stimulation period (including a 30-second ramp-up and 30-second ramp-down period) to the dorsolateral prefrontal cortex. Electrodes will be fixed on marked locations based on the 10-20 EEG system. Anodal stimulating electrode will be over the left DLPFC (F3) and cathodal electrode over the right DLPFC (F4).
  • Sham Stimulation — DEVICE
    electrodes will have the same montage as active tDCS (F3/F4), but current will be ramped down after the initial 30 seconds ramp-up period. Thus, participants will feel the initial sensation associated with tDCS but will receive no active current for the rest of the stimulation period.

Study Details

The overall goal of this study is to investigate the added benefit of a neuromodulation intervention in individuals under buprenorphine maintenance treatment for OUD (bOUD).

Key Dates

Start date
Feb 4, 2026
Status verified
Feb 2026
Primary completion
Aug 1, 2026
Completion
Aug 1, 2026

Study Design

Enrollment
160 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: tDCS
    All intervention sessions will use the Soterix Mini-CT Remote tDCS device
  • Placebo Comparator: Sham Electrodes

Primary Outcome Measure

tDCS effect on circuit-based target engagement of a prefrontal-incentive salience network [ Time Frame: immediately after the intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MinnesotaMinneapolisMinnesota55455
Clarista Berg
[email protected]
612-625-3330

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By research site
University of Minnesota· Minneapolis, MN

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