Genicular Nerve Block for Knee Pain in the ED

Conditions

• Knee Pain

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Genicular nerve block with bupivacaine and corticosteroids — PROCEDURE
  genicular nerve block with ideal body-weight dosing of bupivacaine 0.5% with 4 mg dexamethasone
• Standard of Care — OTHER
  This involves standard of care pain relief for patients who do not receive the genicular nerve block for knee pain, such as acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), and opioids.

Study Details

Patient with atraumatic knee pain without a large knee effusion on x-ray will be randomized to receive either a genicular nerve block (GNB) or standard of care in the emergency department.

Key Dates

Start date

Aug 6, 2025

Status verified

Feb 2026

Primary completion

Aug 1, 2026

Completion

Sep 1, 2026

Study Design

Enrollment

34 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Genicular Nerve Block
  This arm of patients (17 total) will receive the genicular nerve block for their knee pain.
• Active Comparator: Standard of Care
  This arm of patients (17 total) will receive standard of care analgesia for their knee pain

Primary Outcome Measure

Pain level [ Time Frame: 1 hour post-enrollment ]

Central Contacts

• Umar Clinical Research Coordinator, AB
  267-624-4394
  [email protected]

Locations (4)

Find similar trials in Philadelphia, PA

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