Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study

Part of paid clinical trials in Charlottesville, Virginia.

Sponsor
University of Virginia
Study ID
NCT07146685
Phase
PHASE4
Status
Not Yet Recruiting

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Conditions

  • Interscalene Block
  • Rebound Pain
  • Shoulder Arthroplasty

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Bupivacaine — DRUG
    We are comparing two concentrations of the same drug: 10 ml of 0.5% and 20 ml of 0.25%; We will use the same milligram dose (50 mg).

Study Details

Randomized control study that compares different concentrations of local anesthetic to investigate whether a lower concentration of local anesthetic would contribute to lower rebound pain scores at 24 hours post op in patients undergoing anatomic or reverse total shoulder arthroplasty.

Key Dates

Start date
Jan 1, 2026
Status verified
Aug 2025
Primary completion
Jan 1, 2028
Completion
Jan 1, 2029

Study Design

Enrollment
168 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Active Comparator: Concentrated
    Standard management of higher percent local anesthetic: 0.5% Bupivacaine
  • Experimental: Dilute
    More dilute local : 0.25% Bupivacaine

Primary Outcome Measure

Max NRS Pain Score at 24 hours [ Time Frame: 24 hours after intervention; will also be assessed at 48 and 72 hours, though these are not the primary outcome for the study. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UVA HealthCharlottesvilleVirginia22903
Leon N Grinman, DO
[email protected]
434-924-3627

Find similar trials in Charlottesville, VA

By research site
UVA Health· Charlottesville, VA

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